Acute responses of stevia and d‑tagatose intake on metabolic parameters and appetite/satiety in insulin resistance
Verónica Sambra et al.
Clin Nutr ESPEN.
2022 Jun.
Abstract
Objective: To examine the effects of d-‐‑tagatose or
stevia preloads on carbohydrate metabolism markers after an oral glucose
load, as well as subjective and objective appetite in women
with insulin resistance (IR).
Research design and methods: Randomized
controlled crossover study. Women with IR without T2DM (n = 33; aged
23.4 ± 3.8; BMI 28.1 ± 3.4 kg × m‑2) underwent three
oral glucose loads (3h each) on three different days. Ten min before
oral glucose load, volunteers consumed a preload of 60mL
water (control), 60 mL water with stevia (15.3 mg), or
d‑tagatose (5000 mg). Serum glucose and C‑peptide were
evaluated at -10, 30‑, 60‑, 90‑, 120‑, and 180‑min. Subjective
appetite was determined with a visual analog scale. Food
intake was measured at ad libitum buffet after 180 min.
Results: C-peptide iAUC was
significantly higher for stevia (median (IQR): 1033 (711‑1293)
ng × min × L-1) vs. d-tagatose (794 (366-‐‑1134) ng
× min × L‑1; P = 0.001) or control (730 (516‑1078) ng ×
min × L‑1; P = 0.012). At 30‑ and 60‑min serum glucose was
higher for stevia vs other conditions (P < 0.01). Volunteers
reported greater satiety for stevia and d‑tagatose vs. control
at 60 min and greater desire to eat for stevia vs. control at 120‑
min (all P < 0.05). Objective appetite did not vary by condition
(P = 0.06).
Conclusions: Our findings suggest
that these NNS are not inert. Stevia intake produced an acute
response on C‑peptide release while increased serum glucose
at earlier times. It is possible that NNS affects subjective but not
objective appetite. This trial is registered at
clinicaltrials.gov as NCT04327245.
Clinical trial registry: NCT04327245.
Keywords: Appetite; C‑peptide; Glycemia;
Insulin resistance; Satiety; Stevia; d‑tagatose.