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鼠李糖乳杆菌GG和塔格糖作为合生元组合对右旋糖酐硫酸钠诱导结肠炎小鼠模型的影响

Effect of the Lactobacillus rhamnosus strain GG and tagatose as synbiotic combination in a dextran sulfate sodium-induced colitis murine model

J Dairy Sci. 2019 Feb 21. pii: S0022-0302(19)30158-4. doi: 10.3168/jds.2018-15013

Abstract: Synbiotics, a combination of prebiotics and probiotics, produce synergistic effects to promote gastrointestinal health. Herein, we investigated the synbiotic interaction between the Lactobacillus rhamnosus strain GG (LGG; a probiotic strain) and tagatose (a prebiotic) in a dextran sulfate sodium (DSS)-induced colitis murine model. Initially, body weight, food intake, and clinical features were dramatically decreased after treatment with DSS, and the addition of LGG, tagatose, or both ameliorated these effects. In our pyrosequencing analysis of fecal microbiota, DSS treatment increased the abundance of Proteobacteria and decreased that of Firmicutes. When LGG and tagatose were administered as synbiotics, the gut microbiota composition recovered from the dysbiosis caused by DSS treatment. In particular, the abundance of Bacteroides, Lactobacillus, and Akkermansia was significantly associated with probiotic, prebiotic, and synbiotic treatments. Taken together, our results suggest that LGG and tagatose as synbiotics can alleviate colitis, andsynbiotics could be applied as dietary supplements in dairy foods such as yogurt and cheese.

Keywords: DSS-induced colitis; Lactobacillus rhamnosus GG; gut microbiota; synbiotic; tagatose


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